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SSRIs with NSAIDs: How This Common Medication Combo Raises GI Bleeding Risk and What to Do

SSRIs with NSAIDs: How This Common Medication Combo Raises GI Bleeding Risk and What to Do
wayne Holloway in: Medications 4 January 2026

Combining SSRIs and NSAIDs significantly raises the risk of dangerous gastrointestinal bleeding. Learn why this common drug combo is risky, who’s most vulnerable, and what steps to take to stay safe - including safer pain relief options and when to use protective medication.

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