Sofosbuvir: What You Need to Know

Sofosbuvir is a direct-acting antiviral used to treat hepatitis C. It targets the virus's ability to copy itself and is usually given with other drugs like ledipasvir, velpatasvir, or daclatasvir. These combinations cure most people in 8 to 12 weeks.

How it works: Sofosbuvir blocks the HCV polymerase enzyme that copies viral RNA. That stops the virus from multiplying so your immune system can clear the infection. The drug is taken by mouth once daily and is well absorbed with or without food depending on the partner drug.

Who should take it and how

Doctors prescribe sofosbuvir for adults with chronic hepatitis C of various genotypes. The exact combo and treatment length depend on genotype, prior treatment history, and presence of cirrhosis. For example, sofosbuvir/ledipasvir (Harvoni) often runs 12 weeks, while sofosbuvir/velpatasvir (Epclusa) treats all genotypes in 12 weeks for most patients. Your clinician will order blood tests and sometimes a liver scan before starting.

Side effects are usually mild. People report headache, fatigue, nausea, and insomnia most often. Serious reactions are rare but can include allergic responses or worsening liver function in people with advanced disease. Always tell your prescriber about other medicines and supplements you take.

Interactions, testing and safety

Sofosbuvir interacts with few drugs, but some heart medicines, anticonvulsants, and herbal supplements like St. John's wort can lower its effect. Ribavirin may be paired with sofosbuvir but can cause anemia and requires extra monitoring. People with severe kidney failure need special advice; some regimens are not recommended for low kidney function.

Before treatment you'll get HCV RNA and genotype tests, liver and kidney labs, and often hepatitis B screening. During therapy, providers check viral load to confirm response and monitor side effects. After treatment a sustained virologic response (SVR) at 12 weeks means cure in most cases.

Can you buy sofosbuvir online? Some legitimate pharmacies sell generics at lower prices, but fake or substandard products exist. Only use licensed pharmacies, check for a valid pharmacist contact, and avoid sites that skip prescriptions. Compare prices, read pharmacy reviews, and confirm the drug's packaging and batch number when it arrives.

Costs vary widely. Brand-name combos can be expensive in some countries, while quality generics from reputable suppliers may cost less. Talk to your doctor about patient assistance programs, government coverage, or local clinics that offer treatment at lower cost.

If you have hepatitis C, treatment with sofosbuvir-based regimens is often curative. Ask your healthcare team about the best combination for your genotype, drug interactions, and a plan for monitoring. Getting treatment sooner reduces liver damage and lowers long-term risks like cirrhosis and liver cancer.

Quick tips: take the medicine at the same time every day and never stop early. Avoid alcohol while on treatment. Tell your doctor if you're pregnant or planning pregnancy. Men with pregnant partners should use reliable contraception if ribavirin is included. Keep follow-up lab appointments, keep a list of all medicines, and save the drug packaging when it arrives.