Pirfenidone: What You Need to Know

When working with Pirfenidone, an oral anti‑fibrotic medication approved for idiopathic pulmonary fibrosis (IPF). Also known as Esbriet, it slows scar tissue buildup in the lungs and improves breathing function. Idiopathic Pulmonary Fibrosis, a chronic, progressive lung disease with unknown cause is the primary condition pirfenidone targets, and it belongs to the broader class of Anti‑fibrotic Therapy, treatments that aim to reduce or halt fibrotic tissue formation. Understanding these relationships helps you see why dosage, monitoring, and side‑effect management matter.

Key Facts at a Glance

The standard dose of pirfenidone ramps up to 2403 mg daily, split into three doses taken with food to boost absorption and cut gastrointestinal upset. Clinical trials show that patients who stick to the recommended schedule experience a 30‑45% reduction in forced vital capacity decline, meaning lung function holds steadier for longer. Common side effects include nausea, rash, and photosensitivity—sun‑related skin reactions that require sunscreen and protective clothing. Less frequent but serious concerns involve liver enzyme elevations, so regular blood tests are a must during the first few months of therapy. If you notice persistent fatigue, unexplained bruising, or yellowing skin, contact your clinician right away.

Beyond dosing, patient education plays a big role in treatment success. The FDA approved pirfenidone in 2014 after multiple phase III studies proved its efficacy, and health authorities worldwide have adopted similar guidelines. Insurance coverage can be tricky; many plans require prior authorization, so keep prescription details handy. Drug interactions are another puzzle piece—avoid taking strong CYP1A2 inhibitors like fluvoxamine without medical advice, as they can raise pirfenidone levels and increase side‑effect risk. Finally, lifestyle tweaks such as quitting smoking, staying hydrated, and engaging in gentle aerobic exercise complement the medication’s anti‑fibrotic action and help maintain overall lung health.

Now that you know the basics—what pirfenidone treats, how it should be taken, and what to watch for—you’re ready to explore the deeper dive. Below you’ll find articles covering everything from cost‑saving tips when buying generic versions to detailed comparisons of pirfenidone versus other IPF drugs, real‑world patient experiences, and the latest research updates. Use this curated collection to make informed decisions, manage therapy confidently, and stay ahead of any changes in your treatment plan.